Thyroid hormone stimulates renin synthesis in rats without involving the sympathetic nervous system

30 male Sprague-Dawley rats

Daily intraperitoneal administration of methimazole (to induce hypothyroidism) or thyroxine (to induce hyperthyroidism), with or without 6-hydroxydopamine (for sympathetic denervation) for 8 weeks

Daily intraperitoneal administration of saline vehicle (control), with or without saline vehicle (sympathetic innervated)

Plasma renin activity, renal levels of renin, and renal expression of renin mRNAsurrogate