November 1, 1994Journal of Applied Physiology
Effects of maximal exercise and venous occlusion on fibrinolytic activity in physically active and inactive men
Key result
Habitual physical activity in men was associated with greater increases in TPA activity postexercise (P<0.001) and lower baseline PAI-1 activity (P<0.05) compared to inactivity.
Why the study?
Does habitual physical activity level affect changes in fibrinolytic activity in response to maximal exercise and venous occlusion in men?
Population
45 men categorized by habitual physical activity levels
Comparison
Maximal exercise and 5-min venous occlusion vs Comparison among inactive, regularly active, and…
Design
Cross-sectional
Authors
Discussion
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Implication
May support activity for enhanced fibrinolytic responses in men; leaves open causality and outcome benefits in prospective studies.
Study Design
Type
Observational (n=45)
Structured PICO
Does habitual physical activity level affect changes in fibrinolytic activity in response to maximal exercise and venous occlusion in men?
P
Population
45 men categorized as inactive, regularly active, or highly active, assessed for fibrinolytic activity responses to maximal exercise and venous occlusion.
E
Exposure
Maximal exercise and 5-min venous occlusion
C
Comparator
Comparison among inactive, regularly active, and highly active groups
O
Outcome
Changes in Tissue plasminogen activator (TPA) activity and plasminogen activator inhibitor 1 (PAI-1) activitysurrogate
Main Result
p-value: p=<0.001
Regular physical activity enhances fibrinolytic activity responses to maximal exercise and venous occlusion, which may be an important mechanism for its cardioprotective effects.
Cite This Study
Szymanski et al. (1994) reported an observational. Habitual physical activity (regularly or highly active) vs. Inactive was evaluated on Changes in tissue plasminogen activator (TPA) and plasminogen activator inhibitor 1 (PAI-1) activity (p=<0.001). Habitual physical activity in men was associated with greater increases in TPA activity postexercise (P<0.001) and lower baseline PAI-1 activity (P<0.05) compared to inactivity.