Key result
Pretreatment with acetazolamide or breathing 4% CO2 significantly increased plasma norepinephrine during 175-W exercise compared to control (1866 and 1842 vs 951 pg/ml, respectively; P<0.01).
Why the study?
Does altering acid-base status influence plasma catecholamine levels during exercise in healthy volunteers?
Does altering acid-base status influence plasma catecholamine levels during exercise in healthy volunteers?
Absolute Event Rate: 1866% vs 951%
p-value: p=<0.005
Acidosis induced by acetazolamide or CO2 inhalation significantly increases plasma norepinephrine levels during exercise in healthy humans.
May enhance sympathetic activation during intense exercise in healthy subjects; leaves open effects on performance or relevance to patients.
The influence of acid-base status on plasma catecholamines during exercise was investigated in six healthy volunteers. Incremental exercise to 175 W was performed on a bicycle ergometer under four conditions: 1) control, 2) during forced hyperventilation (HV), 3) after pretreatment with acetazolamide (AZE), and 4) while breathing 4% CO2. Resting plasma norepinephrine (PNE) and epinephrine (PE) were not different among the four protocols despite higher resting pH during HV and lower resting pH after AZE [control, 7.4 +/- 0.02; HV, 7.48 +/- 0.03 (P less than 0.005); AZE, 7.36 +/- 0.01 (P less than 0.005) (P values indicate significant differences from the control protocol)]. Resting pH was not different from control during the 4% CO2 study (7.4 +/- 0.01). At the 175-W exercise load, there were significant differences in both pH and PNE. During the control test, pH was 7.38 +/- 0.02, PNE was 951 +/- 164 pg/ml, and PE was 264 +/- 132 pg/ml. During HV, pH was 7.46 +/- 0.5 (P less than 0.001), PNE was 976 +/- 67 pg/ml, and PE was 210 +/- 27 pg/ml. After AZE, pH was 7.31 +/- 0.2 (P less than 0.001), PNE was 1,866 +/- 561 pg/ml (P less than 0.005), and PE was 382 +/- 264 pg/ml. While subjects breathed 4% CO2, pH was 7.29 +/- 0.02 (P less than 0.001), PNE was 1.842 +/- 617 pg/ml (P less than 0.01), and PE was 467 +/- 275 pg/ml.(ABSTRACT TRUNCATED AT 250 WORDS)
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Goldsmith et al. (1990) studied Healthy volunteers (n=6). Acetazolamide or 4% CO2 breathing vs. Control condition was evaluated on Plasma norepinephrine (PNE) at 175-W exercise load (p=<0.005). Pretreatment with acetazolamide or breathing 4% CO2 significantly increased plasma norepinephrine during 175-W exercise compared to control (1866 and 1842 vs 951 pg/ml, respectively; P<0.01).
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