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January 1, 1995Applied Human Science Journal of Physiological AnthropologyOpen Access

Relationship among Blood Lactate and Plasma Catecholamine Levels during Exercise in Acute Hypoxia.

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Key result

Acute hypoxia during exercise increased blood lactate accumulation, which significantly correlated with plasma epinephrine (P<0.01) and norepinephrine (P<0.01).

Why the study?

Does acute hypoxia during exercise increase blood lactate and plasma catecholamine levels in male subjects?

Population

n=5 male subjects

Comparison

Steady exercise on a cycle ergometer at an… vs Steady exercise on a cycle ergometer at an…

Design

Other

Authors

HTHiromi TakahashiThe University of OsakaMLMasanori lrizawaTKTakashi KomuraShimane University

Discussion

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Member takes

Overview

May link catecholamines to lactate accumulation in hypoxic exercise; hypothesis-generating and requires confirmation before clinical consideration.

Structured PICO

Does acute hypoxia during exercise increase blood lactate and plasma catecholamine levels in male subjects?

P
Population
5 male subjects performing steady exercise on a cycle ergometer under varying levels of acute hypoxia.
I
Intervention
Steady exercise on a cycle ergometer at an intensity of 60% maximal O2 uptake (VO2max) for 6 min while breathing hypoxic gas mixtures (12% or 16% O2 in N2)
C
Comparator
Steady exercise on a cycle ergometer at an intensity of 60% maximal O2 uptake (VO2max) for 6 min while breathing normoxic gas mixture (21% O2 in N2)
O
Outcome
Blood lactate (La) and plasma catecholamines (epinephrine and norepinephrine) levels immediately after exercisesurrogate

Main Result

p-value: p=<0.01

Acute hypoxia during exercise increases blood lactate accumulation, which correlates significantly with plasma catecholamine levels, suggesting a link between glycogen metabolism and sympathoadrenal activity.

Cite This Study

Takahashi et al. (1995) studied this question. Hypoxic gas mixtures vs. Normoxia (21% O2 in N2) was evaluated on Correlation between blood lactate and plasma catecholamines (epinephrine and norepinephrine) during exercise (p=<0.01). Acute hypoxia during exercise increased blood lactate accumulation, which significantly correlated with plasma epinephrine (P<0.01) and norepinephrine (P<0.01).

synapsesocial.com/papers/6a9ed5802ccf4465eebe32c6https://doi.org/10.2114/ahs.14.49
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypoxemia increases plasma catecholamine concentrations in exercising humans1984 · 87 citations
  2. 2Arterial Catecholamines in Hypoxic Exercise in Man1975 · 26 citations
  3. 3Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure1991 · 189 citations
  4. 4Effect of beta-adrenergic blockade on lactate turnover in exercising dogs1984 · 48 citations
  5. 5Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans.1988 · 344 citations