Key result
Matrix metalloproteinases play a key role in cardiovascular remodeling, plaque vulnerability, and restenosis, suggesting MMP-targeted therapies may help prevent atherosclerotic lesion development.
Matrix metalloproteinases are implicated in atherosclerotic plaque vulnerability and restenosis, suggesting they may be potential therapeutic targets in coronary artery disease.
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Should not yet change CAD management; leaves open MMP inhibition as a hypothesis-generating target for future trials.
Ikeda et al. (2003) conducted a review in Coronary artery diseases. Matrix metalloproteinases (MMPs) was evaluated. Matrix metalloproteinases play a key role in cardiovascular remodeling, plaque vulnerability, and restenosis, suggesting MMP-targeted therapies may help prevent atherosclerotic lesion development.