What is the clinical evidence from this study?

Study design: Other. Population: Arterial pressure overload. Intervention: Dietary supplementation with omega-3 PUFA from fish oil vs. Standard chow. Primary outcome: Increase in LV mass.

July 12, 2007Cardiovascular ResearchOpen Access

Dietary supplementation with ω-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload

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Key result

Dietary supplementation with omega-3 PUFA attenuated pressure overload-induced LV mass increase (18% vs 31% with standard chow) and prevented increases in LV volumes in male Wistar rats.

Why the study?

Does dietary supplementation with omega-3 PUFA attenuate ventricular remodeling and dysfunction in male Wistar rats with pressure overload?

Population

Male Wistar rats undergoing abdominal aortic banding or sham surgery (n=9-12/group)

Comparison

Dietary supplementation with omega-3… vs Standard chow

Design

Preclinical

Follow-up

8 weeks

Authors

MDMonika DudaPostgraduate School of Molecular Medicine KOKaren M. O’SheaUniversity of Maryland, Baltimore BBBrian R. BarrowsNational Academies of Sciences, Engineering, and Medicine

Discussion

Member takes

Implication

Hypothesis-generating in rodent pressure-overload models; leaves open translation to human ventricular remodeling.

Structured PICO

Does dietary supplementation with omega-3 PUFA attenuate ventricular remodeling and dysfunction in male Wistar rats with pressure overload?

Population

Male Wistar rats subjected to abdominal aortic banding or sham surgery, followed for 8 weeks.

Intervention

Dietary supplementation with omega-3 polyunsaturated fatty acids (omega-3 PUFA) from fish oil

Comparator

Standard chow

Outcome

Left ventricular function and remodeling (LV mass, LV end diastolic and systolic volumes) assessed by echocardiography after 8 weekssurrogate

Main Result

Absolute Event Rate: 18% vs 31%

Dietary supplementation with omega-3 PUFA attenuates pressure overload-induced left ventricular dysfunction and remodeling in a rat model, potentially mediated by elevated plasma adiponectin.

Cite This Study

Duda et al. (2007) studied Arterial pressure overload. Dietary supplementation with omega-3 PUFA from fish oil vs. Standard chow was evaluated on Increase in LV mass. Dietary supplementation with omega-3 PUFA attenuated pressure overload-induced LV mass increase (18% vs 31% with standard chow) and prevented increases in LV volumes in male Wistar rats.

synapsesocial.com/papers/6a93125b6e9832cd69152ff8 https://doi.org/10.1016/j.cardiores.2007.07.002

View Full Paper

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Bookmark

Dietary supplementation with ω-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Dietary supplementation with ω-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider