Key result
Dietary supplementation with 1.25% fish oil significantly reduced relative heart weight compared to control (3.3 vs 4.8 g/kg) and shortened QTc intervals in a rabbit model of heart failure.
Why the study?
Does a diet rich in unsaturated fatty acids (high oleic sunflower oil or fish oil) prevent progression toward heart failure and electrophysiologic remodeling in a rabbit model of pressure and volume overload?
Population
Rabbit model of heart failure induced by volume and pressure overload (N=30)
Comparison
Diet containing 1.25% high oleic sunflower oil… vs No supplement (HF-control)
Design
Preclinical
Follow-up
4 months
Authors
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Dietary FA modulation warrants testing in HF models; leaves open whether ω3-FAs prevent arrhythmias in patients.
Does a diet rich in unsaturated fatty acids (high oleic sunflower oil or fish oil) prevent progression toward heart failure and electrophysiologic remodeling in a rabbit model of pressure and volume overload?
Absolute Event Rate: 3.3% vs 4.8%
Dietary unsaturated fatty acids, particularly fish oil, started prior to heart failure induction prevent hypertrophy, heart failure progression, and electrophysiologic remodeling in a rabbit model.
Ruijter et al. (2012) studied Heart failure (n=30). Dietary unsaturated fatty acids (fish oil or high oleic sunflower oil) vs. No supplement was evaluated on Relative heart weight (g/kg). Dietary supplementation with 1.25% fish oil significantly reduced relative heart weight compared to control (3.3 vs 4.8 g/kg) and shortened QTc intervals in a rabbit model of heart failure.
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