Key result
Obstructive coronary artery disease evaluated by coronary CTA was associated with a significantly higher risk of all-cause mortality in cancer patients (HR 1.845).
Why the study?
The study was conducted to evaluate the prognostic value of coronary CTA to predict all-cause mortality risk in cancer patients using a propensity score matching analysis.
Does obstructive CAD evaluated by coronary CTA predict all-cause mortality in cancer patients?
Cohort (n=331)
No
Does obstructive CAD evaluated by coronary CTA predict all-cause mortality in cancer patients?
Hazard Ratio: 1.845 (95% CI 1.008–3.377)
Absolute Event Rate: 13% vs 6.4%
p-value: p=0.047
Obstructive coronary artery disease identified by coronary CTA is an independent predictor of all-cause mortality in cancer patients, highlighting its potential utility for cardiovascular risk stratification in cardio-oncology.
Obstructive CAD on CTA associated with mortality in cancer patients; leaves open whether CTA improves risk stratification.
The aim of this study was to evaluate the prognostic value of coronary computed tomography angiography (CTA) to predict the risk of all-cause mortality in cancer patients in a propensity score matching (PSM) analysis. A total of 331 patients who previously had cancer and underwent coronary CTA from January 2015 to December 2019 were included. Multivariate Cox proportional hazards regression analysis and propensity-score matching analysis were performed. The primary endpoint was all-cause of mortality. In total, 125 with obstructive coronary artery disease (CAD) and 206 with non-obstructive CAD during a median follow-up of 3.3 years were included in this study. After PSM, age (HR, 1.040; 95%CI, 1.001-1.081; p =0.046), smoking history (HR, 2.344; 95%CI, 1.211-4.536; p =0.011), diabetes mellitus (HR, 1.862; 95%CI, 1.053-3.292; p =0.033) and obstructive CAD (HR, 1.845; 95%CI, 1.008-3.377; p =0.047) remained significant factors for all-cause mortality. Obstructive CAD evaluated by coronary CTA was found to be at higher risk for developing all-cause mortality in cancer patients.
No takes yet. Share an insight, caveat, or question.
Huang et al. (2022) conducted a cohort in Cancer with suspected coronary artery disease (n=331). Obstructive coronary artery disease vs. Non-obstructive coronary artery disease was evaluated on All-cause mortality (HR 1.845, 95% CI 1.008-3.377, p=0.047). Obstructive coronary artery disease evaluated by coronary CTA was associated with a significantly higher risk of all-cause mortality in cancer patients (HR 1.845).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: