The fine structural characteristics of a case of perianal Paget's disease are presented. These include the presence of secretory and nonsecretory Paget's cells forming lumens and intercellular canaliculi, pleomorphic mitochondria, fine cytoplasmic filaments, convoluted plasma membranes containing microvilli, and poorly developed desmosomes. These findings are interpreted as favoring an eccrine sweat gland origin in the extramammary and lactiferous ductal origin in the mammary form of the disease. Insofar as the histogenetic origin of Paget's cells is concerned, the assumption of epidermotropic migration from an underlying carcinoma is favored over the concept of malignant conversion of the intra-epidermal sudoriferous or squamous epithelium.
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Ferenczy et al. (1972) studied this question.
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