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October 11, 2017Journal of the American Heart AssociationOpen Access

Low Prevalence of Inappropriate Shocks in Patients With Inherited Arrhythmia Syndromes With the Subcutaneous Implantable Defibrillator Single Center Experience and Long‐Term Follow‐Up

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Key result

Subcutaneous ICD use in 62 patients with inherited arrhythmia syndromes effectively terminated all 20 spontaneous ventricular tachyarrhythmias, with only 2 patients experiencing inappropriate shocks.

Why the study?

Does the subcutaneous implantable cardioverter-defibrillator effectively and safely treat ventricular arrhythmias in patients with inherited arrhythmia syndromes?

Population

62 consecutive patients with primary hereditary arrhythmia syndromes fulfilling indication for defibrillator…

Design

Cohort

Follow-up

mean 31.0±14.2 months

Authors

BRBoris RudicElectrophysiologyETErol TülümenKoç UniversityVBVeronika BerlinHeidelberg University

Discussion

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Overview

Supports S-ICD first-shock efficacy in inherited syndromes; leaves open need for randomized trials before practice change.

Study Design

Type

Cohort (n=62)

Multicenter

No

Structured PICO

Does the subcutaneous implantable cardioverter-defibrillator effectively and safely treat ventricular arrhythmias in patients with inherited arrhythmia syndromes?

P
Population
62 consecutive patients with primary hereditary arrhythmia syndromes without indication for antibradycardia therapy, followed for a mean of 31.0 months.
E
Exposure
Subcutaneous implantable cardioverter-defibrillator (S-ICD)
O
Outcome
Efficacy in detection and treatment of ventricular arrhythmias, inappropriate therapies, and complications (infections, premature revisions)safety

The subcutaneous ICD is an effective and safe alternative to transvenous ICDs for primary and secondary prevention of sudden cardiac death in patients with inherited arrhythmia syndromes, demonstrating reliable shock efficacy and a low rate of inappropriate shocks.

Cite This Study

Rudic et al. (2017) conducted a cohort in Inherited Arrhythmia Syndromes (n=62). Subcutaneous Implantable Defibrillator (S-ICD) was evaluated on Efficacy and safety of subcutaneous ICD (appropriate shocks, inappropriate therapies, infections). Subcutaneous ICD use in 62 patients with inherited arrhythmia syndromes effectively terminated all 20 spontaneous ventricular tachyarrhythmias, with only 2 patients experiencing inappropriate shocks.

synapsesocial.com/papers/6a93205ec2b35ebf92c13f2ehttps://doi.org/10.1161/jaha.117.006265
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Worldwide experience with a totally subcutaneous implantable defibrillator: early results from the EFFORTLESS S-ICD Registry2014 · 463 citations
  2. 2An Entirely Subcutaneous Implantable Cardioverter–Defibrillator2010 · 781 citations
  3. 3Safety and Efficacy of the Totally Subcutaneous Implantable Defibrillator2015 · 500 citations
  4. 4How many patients fulfil the surface electrocardiogram criteria for subcutaneous implantable cardioverter-defibrillator implantation?2013 · 96 citations
  5. 5Which Patients Are Not Suitable for a Subcutaneous ICD: Incidence and Predictors of Failed QRS‐T‐Wave Morphology Screening2013 · 132 citations