Key result
In isolated guinea pig left atria, thiopental was a more potent myocardial depressant than propofol, with a significantly lower IC50 for peak twitch tension (20.9 vs 96.6 μM, P<0.05).
Why the study?
Does propofol have different myocardial depressive effects compared to thiopental in isolated guinea pig left atria?
Does propofol have different myocardial depressive effects compared to thiopental in isolated guinea pig left atria?
Absolute Event Rate: 20.9% vs 96.6%
p-value: p=< 0.05
In an isolated guinea pig left atrial model, thiopental is a more potent myocardial depressant than propofol, especially when compared relative to anesthetic potencies.
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Alerts to potential differences in myocardial depression between agents; leaves open clinical translation from this isolated atrial model.
Azari et al. (1993) studied this question. Thiopental vs. Propofol (56 μM to 2800 μM) was evaluated on IC50 for peak twitch tension (p=< 0.05). In isolated guinea pig left atria, thiopental was a more potent myocardial depressant than propofol, with a significantly lower IC50 for peak twitch tension (20.9 vs 96.6 μM, P<0.05).
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