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Many centrally acting cholinoceptive receptor blocking drugs reduce the level of cerebral acetylcholine (Ach) in the rat Of the drugs tested hyoscine hydrobromide was the most effective and the reduction in Ach content was restricted to the cerebral hemispheres The decrease of brain Ach caused by hyoscine was also shown to occur in the guinea-pig
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Bartolini et al. (1967) studied this question.
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