Key result
A T-lymphocyte clone derived from a twin with multiple sclerosis proliferated specifically in response to measles virus (4,858 cpm) compared to uninfected cells (289 cpm), but not to mumps, vaccinia, or canine distemper viruses.
Population
Measles virus-specific T lymphocyte clone derived from a measles-responder twin with multiple sclerosis
Design
Preclinical
Authors
Loading...
Hypothesis-generating for measles-specific T-cell responses in MS; leaves open causal role and clinical relevance.
Absolute Event Rate: 4858% vs 289%
A measles virus-specific T cell clone from an MS patient was characterized as a helper/inducer T cell that recognizes measles antigen presented in association with a gene product linked to HLA-DRw2.
Richert et al. (1983) studied Multiple sclerosis (n=2). Measles virus antigens (Edmonston strain) vs. Uninfected Vero cells and other viruses was evaluated on Proliferative response of cloned T cells measured by [3H]Thymidine incorporation (cpm) at 48 hours. A T-lymphocyte clone derived from a twin with multiple sclerosis proliferated specifically in response to measles virus (4,858 cpm) compared to uninfected cells (289 cpm), but not to mumps, vaccinia, or canine distemper viruses.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: