Key result
Incubation with 10 or 100 ng of myelin basic protein doubled or tripled the cytotoxicity of measles-specific cytotoxic T lymphocytes against measles virus-infected targets.
Population
Peripheral blood lymphocytes from normal volunteers
Comparison
Incubation with 10 or 100 ng myelin basic… vs Bovine serum albumin
Design
Preclinical
Authors
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May support molecular mimicry in MS; hypothesis-generating in animal models only.
Demonstrates cross-reactivity between measles virus-specific cytotoxic T-cells and myelin basic protein, suggesting a potential mechanism for multiple sclerosis pathogenesis.
Matossian-Rogers et al. (2009) studied Multiple sclerosis. Myelin basic protein (MBP) vs. Bovine serum albumin or no reagent was evaluated on Cytotoxicity (specific release of radioisotope in 51Cr release assay). Incubation with 10 or 100 ng of myelin basic protein doubled or tripled the cytotoxicity of measles-specific cytotoxic T lymphocytes against measles virus-infected targets.
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