Key result
A newly developed real-time RT-PCR kit successfully detected HAV genotype IIIA, which had evaded commercially available HAV RNA detection systems in a German blood donation.
Population
A blood donation obtained in 2003 in Germany during the preseroconversion diagnostic window period of a…
Comparison
Development of a real-time RT-PCR kit for… vs Commercially available HAV reverse…
Design
Other
Authors
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May warrant updated HAV RNA assays for blood safety; leaves open broader validation before routine adoption.
Case Report (n=1)
The identification of HAV genotype IIIA in Germany highlights the need for continuous adaptation of diagnostic nucleic acid assays to ensure blood product safety.
Heitmann et al. (2005) conducted a case report in Hepatitis A virus (HAV) infection (n=1). Newly developed real-time RT-PCR kit vs. Commercially available HAV RT-PCR detection assays was evaluated on Detection of HAV genotype IIIA. A newly developed real-time RT-PCR kit successfully detected HAV genotype IIIA, which had evaded commercially available HAV RNA detection systems in a German blood donation.
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