What question did this study set out to answer?

To determine whether intentional weight loss achieved through dietary change mitigates colon and liver carcinogenesis following chemical induction in diet-induced obese mice.

September 9, 2016AJP Gastrointestinal and Liver PhysiologyOpen Access

Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model

View Full Paper

Ask AI

Bookmark

Authors

KVKandy T. VelázquezUniversity of South Carolina REReilly T. EnosUniversity of South Carolina MCMeredith S. CarsonUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Animal study reveals intentional weight loss fails to reduce colon tumorigenesis in obese mice, suggesting post-obesity dietary changes may not reverse chemically induced cancer risk.

Key Points

To determine whether intentional weight loss achieved through dietary change mitigates colon and liver carcinogenesis following chemical induction in diet-induced obese mice.
Mice were fed a high-fat diet (40% fat) for 20 weeks to model human obesity, followed by azoxymethane (AOM) administration to induce colon and liver tumorigenesis.
A subset of obese mice was transitioned to a low-fat diet (12.2% fat) to promote intentional weight loss and fat reduction.
Intentional weight loss significantly improved blood glucose and leptin levels but failed to prevent colon cancer progression or liver dysplastic lesions.
Weight-reduced mice displayed histological liver dysplasia along with elevated percentages of F4/80+CD206+ macrophages in the spleen and activated CD4+CD69+ T cells in lymph nodes.
Mice maintained continuously on a high-fat diet exhibited marked cellular proliferation and pNF-κB activation in liver tissue.

Cite This Study

Velázquez et al. (2016) studied this question.

synapsesocial.com/papers/6a932526c2b35ebf92c13fc9 https://doi.org/10.1152/ajpgi.00207.2016

View Full Paper

Ask AI

Bookmark

Implication

Animal study reveals intentional weight loss fails to reduce colon tumorigenesis in obese mice, suggesting post-obesity dietary changes may not reverse chemically induced cancer risk.

Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model

Discussion

Member takes

Implication

Key Points

Cite This Study

Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider