Why the study?
Does the amount and source of dietary fat influence azoxymethane-induced colon carcinogenesis in female F344 rats?
Population
Female F344 rats treated with azoxymethane (AOM) to induce colon tumors
Comparison
High-fat diets containing 23.52% corn oil… vs Low-fat diets containing 5% CO, 5% SO, or 5% OO
Design
Preclinical
Follow-up
Until the termination of the experiment
Authors
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High corn/safflower oil may promote rat colon tumors; leaves open relevance to human dietary fat guidelines.
Does the amount and source of dietary fat influence azoxymethane-induced colon carcinogenesis in female F344 rats?
Both the amount and fatty acid composition of dietary fat are important factors in promoting colon carcinogenesis in a rat model.
Reddy et al. (1984) studied this question.
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