Key result
This review summarizes current knowledge on how viruses control cellular mRNA degradation machinery to facilitate viral gene expression and elude immune surveillance during infection.
The review highlights mechanisms by which viruses manipulate host cellular mRNA degradation machinery to facilitate infection and evade immune surveillance.
Viral RNA shutoff may inform cardiac infection management; leaves open targeted host mRNA pathway studies in pathogenesis.
Cellular RNA decay machinery plays a vital role in regulating gene expression by altering the stability of mRNAs in response to external stresses, including viral infection. In the primary infection, viruses often conquer the host cell's antiviral immune response by controlling the inherently cellular mRNA degradation machinery to facilitate viral gene expression and establish a successful infection. This review summarizes the current knowledge about the diverse strategies of viral-mediated regulatory RNA shutoff for pathogenesis, and particularly sheds a light on the mechanisms that viruses evolve to elude immune surveillance during infection.
No takes yet. Share an insight, caveat, or question.
Du et al. (2018) conducted a review in Viral infection. Viral-mediated regulatory RNA shutoff was evaluated. This review summarizes current knowledge on how viruses control cellular mRNA degradation machinery to facilitate viral gene expression and elude immune surveillance during infection.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: