Key result
Viruses manipulate host-gene expression at the level of mRNA decay, including the deadenylation-dependent pathway, to evade host antiviral responses and enable viral survival and replication.
This review summarizes how viruses manipulate host cellular RNA decay pathways to evade antiviral responses and promote viral replication.
Highlights viral RNA decay manipulation in infections; leaves open targeted antiviral development pending validation.
Viruses alter host-cell gene expression at many biochemical levels, such as transcription, translation, mRNA splicing and mRNA decay in order to create a cellular environment suitable for viral replication. In this review, we discuss mechanisms by which viruses manipulate host-gene expression at the level of mRNA decay in order to enable the virus to evade host antiviral responses to allow viral survival and replication. We discuss different cellular RNA decay pathways, including the deadenylation-dependent mRNA decay pathway, and various strategies that viruses exploit to manipulate these pathways in order to create a virus-friendly cellular environment.
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Guo et al. (2018) conducted a review in Viral infection. Viral manipulation of host mRNA decay was evaluated. Viruses manipulate host-gene expression at the level of mRNA decay, including the deadenylation-dependent pathway, to evade host antiviral responses and enable viral survival and replication.
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