Key result
The 5'-phosphate of the activator is a crucial structural determinant for efficient RNase L activation, with its loss causing a 2-3 orders of magnitude decrease in activator affinity.
Population
Ribonuclease L (RNase L) enzyme model
Design
Preclinical
Authors
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Should not yet influence antiviral strategies; extends mechanistic understanding of RNase L activation for future research.
The 5'-phosphate of the activator is crucial for the efficient activation of RNase L, while the length of the activator is less important for potency.
Carroll et al. (1997) studied this question. Synthetic analogs of 2',5'-oligoadenylates vs. Native activator was evaluated on Activation of RNase L. The 5'-phosphate of the activator is a crucial structural determinant for efficient RNase L activation, with its loss causing a 2-3 orders of magnitude decrease in activator affinity.
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