Key result
Inspiratory capacity apnea evoked significant fMRI signal increases in multiple brain areas, including the rostral lateral medulla and anterior insula, correlated with MSNA (P<0.01).
Observational (n=15)
p-value: p=<0.01
The sustained increase in muscle sympathetic nerve activity during an inspiratory capacity apnea originates from a distributed set of discrete brain areas.
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Maps human brain sites for apnea-induced sympathoexcitation; leaves open relevance to clinical autonomic disorders.
Macefield et al. (2005) conducted an observational in Healthy (n=15). Inspiratory capacity apnea was evaluated on Whole brain correlations between changes in signal intensity and the known pattern of muscle sympathetic nerve activity (MSNA) (p=<0.01). Inspiratory capacity apnea evoked significant fMRI signal increases in multiple brain areas, including the rostral lateral medulla and anterior insula, correlated with MSNA (P<0.01).
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