Key result
Vitamin E and vitamin E-nicotinate inhibited platelet aggregation induced by the simultaneous addition of adenosine diphosphate and hydrogen peroxide in vitro.
Why the study?
Does vitamin E inhibit platelet aggregation induced by combined ADP and hydrogen peroxide in vitro?
Does vitamin E inhibit platelet aggregation induced by combined ADP and hydrogen peroxide in vitro?
In vitro, vitamin E and vitamin E-nicotinate inhibit platelet aggregation induced by the simultaneous addition of ADP and hydrogen peroxide, likely due to their antioxidant activity.
Supports in vitro antioxidant effects on platelets; hypothesis-generating and should not change practice without in vivo data.
Hydrogen peroxide can either induce or inhibit or enhance the platelet aggregation in vitro depending upon the experimental conditions. Vitamin E and vitamin E-nicotinate are found to be effective to inhibit, to some extent, the platelet aggregation induced by combined adenosine diphosphate (ADP) and hydrogen peroxide (H2O2), added simultaneously, to the platelet rich plasma (PRP). Vitamin E and vitamin E-nicotinate seemed, however, to be unable to prevent the reduction of platelet response to ADP, which was brought about by the pretreatment of PRP with H2O2 of a lower concentration.
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Higashi et al. (1977) studied Healthy. Vitamin E and vitamin E-nicotinate vs. Ethanol control was evaluated on Platelet aggregation induced by combined ADP and H2O2. Vitamin E and vitamin E-nicotinate inhibited platelet aggregation induced by the simultaneous addition of adenosine diphosphate and hydrogen peroxide in vitro.
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