Key result
Celiprolol and atenolol were equally effective in reducing angina frequency and delaying ischaemia onset, but celiprolol produced less heart rate suppression and did not lower cardiac output.
Why the study?
Does celiprolol improve angina and cardiac function compared to atenolol in patients with stable angina pectoris?
RCT (n=16)
Double-blind
Does celiprolol improve angina and cardiac function compared to atenolol in patients with stable angina pectoris?
Celiprolol is as effective as atenolol in reducing angina frequency but has less suppressive effects on heart rate and cardiac output, suggesting potential benefits of its ancillary properties.
Favors celiprolol when preserving HR or output matters in stable angina; extends RCT evidence for beta-blockers with ancillary properties.
Celiprolol (400 mg) and atenolol (100 mg) were given once a day to 16 patients with stable angina pectoris in a double blind placebo controlled crossover study. Celiprolol produced less suppression of heart rate both at rest and during exercise than atenolol. Both drugs were equally effective in reducing the frequency of angina and in delaying the onset of ischaemia during exercise. Radionuclide ventriculography showed that atenolol but not celiprolol lowered cardiac output at rest and during exercise. Thus the ancillary properties of celiprolol, including partial beta 2 agonist activity and direct vasodilating activity, have detectable effects on cardiac function that may be beneficial in patients with angina.
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McLenachan et al. (1988) conducted an RCT in stable angina pectoris (n=16). Celiprolol vs. Atenolol (100 mg once a day) and placebo was evaluated on Frequency of angina and onset of ischaemia during exercise. Celiprolol and atenolol were equally effective in reducing angina frequency and delaying ischaemia onset, but celiprolol produced less heart rate suppression and did not lower cardiac output.
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