Key result
Single intravenous doses of celiprolol improved left ventricular end-systolic volume and ejection fraction (P<0.05), whereas metoprolol caused deterioration in cardiac output and ejection fraction.
Why the study?
Does a single intravenous dose of celiprolol improve acute haemodynamic profiles compared to metoprolol in patients with coronary artery disease and hypertension?
Population
30 patients with coronary artery disease and hypertension
Comparison
Single intravenous dose of 0.15 mg kg-1 celiprolol vs Single intravenous dose of metoprolol
Design
RCT, randomized, double-blind
Authors
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Supports acute IV celiprolol over metoprolol in CAD+HTN to preserve LV function; extends RCT evidence on differential beta-blocker haemodynamics.
RCT (n=30)
Double-blind
randomized
Does a single intravenous dose of celiprolol improve acute haemodynamic profiles compared to metoprolol in patients with coronary artery disease and hypertension?
p-value: p=<0.05
Celiprolol demonstrates a more favorable acute haemodynamic profile compared to metoprolol in patients with concurrent coronary artery disease and hypertension, avoiding myocardial depression.
Heublein et al. (1991) conducted an RCT in coronary artery disease and hypertension (n=30). Celiprolol vs. Metoprolol was evaluated on Haemodynamic effects including left ventricular end-systolic volume and ejection fraction (p=<0.05). Single intravenous doses of celiprolol improved left ventricular end-systolic volume and ejection fraction (P<0.05), whereas metoprolol caused deterioration in cardiac output and ejection fraction.
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