Key result
Celiprolol significantly reduced 24-hour ambulatory blood pressure and total peripheral resistance without decreasing cardiac output in patients with essential hypertension.
Why the study?
Does celiprolol reduce 24-hour ambulatory blood pressure and improve hemodynamics in patients with mild to moderate essential hypertension?
Population
11 outpatients with mild to moderate essential hypertension, mean age 47.5 years, 36% male, based in Japan…
Comparison
Celiprolol 200 mg oral once daily for 4 to 6… vs Baseline control period.
Design
Cohort
Follow-up
mean 18.8 weeks (range 12-22 weeks)
Authors
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May support celiprolol for hypertension with preserved output; leaves open RCT confirmation before practice change.
Does celiprolol reduce 24-hour ambulatory blood pressure and improve hemodynamics in patients with mild to moderate essential hypertension?
Absolute Event Rate: 137.7% vs 148.3%
p-value: p=<0.05
Celiprolol effectively lowers blood pressure in essential hypertension by reducing total peripheral resistance without compromising cardiac output, particularly during waking hours.
Deguchi et al. (1990) studied Essential hypertension (n=11). Celiprolol vs. Baseline/Control period (placebo) was evaluated on 24-hour ambulatory systolic blood pressure (mmHg) (p=<0.05). Celiprolol significantly reduced 24-hour ambulatory blood pressure and total peripheral resistance without decreasing cardiac output in patients with essential hypertension.
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