Key result
Celiprolol 200 mg and 400 mg daily significantly lowered seated mean blood pressure compared to placebo (P<0.05), with no significant difference between the two doses.
Why the study?
Does celiprolol 200 mg or 400 mg daily reduce blood pressure in patients with mild to moderate essential hypertension compared to placebo?
Population
26 hospital out-patients with mild to moderate essential hypertension
Comparison
Celiprolol 200 mg or 400 mg oral daily for 4 weeks vs Matching placebo for 4 weeks
Design
RCT, randomized 3-way crossover, double-blind
Follow-up
4 weeks per treatment period
Authors
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Celiprolol 200-400 mg daily lowers BP in mild-moderate hypertension; reinforces cardioselective beta-blocker efficacy versus placebo in RCTs.
RCT (n=26)
Double-blind
3-way crossover
Yes
Does celiprolol 200 mg or 400 mg daily reduce blood pressure in patients with mild to moderate essential hypertension compared to placebo?
p-value: p=<0.05
Celiprolol 200 mg daily is as effective as 400 mg daily in lowering blood pressure in mild to moderate essential hypertension, with both doses being superior to placebo.
Trafford et al. (1989) conducted an RCT in mild to moderate essential hypertension (n=26). celiprolol vs. placebo was evaluated on seated mean systolic and diastolic blood pressure (p=<0.05). Celiprolol 200 mg and 400 mg daily significantly lowered seated mean blood pressure compared to placebo (P<0.05), with no significant difference between the two doses.
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