January 1, 1986Journal of Cardiovascular Pharmacology
Effects of Celiprolol on Reflex Control of the Cardiovascular System in Essential Hypertension
Why the study?
Does celiprolol alter reflex control of the cardiovascular system in subjects with essential hypertension?
Population
n=6 essential hypertensive subjects
Comparison
Celiprolol 200-400 mg oral once a day for 5-7 days vs Baseline (before treatment)
Design
Cohort
Follow-up
5-7 days
Authors
Discussion
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Implication
Supports preserved baroreflex control with celiprolol in essential hypertension; leaves open confirmation in randomized trials and long-term outcomes.
Structured PICO
Does celiprolol alter reflex control of the cardiovascular system in subjects with essential hypertension?
P
Population
n=6 essential hypertensive subjects
I
Intervention
Celiprolol 200-400 mg oral once a day for 5-7 days
C
Comparator
Baseline (before treatment)
O
Outcome
Reflex control of circulation (blood pressure, heart rate, central venous pressure, forearm blood flow and resistance) during alterations in arterial baroreceptor activitysurrogate
Short-term treatment with celiprolol lowers blood pressure and induces vasodilation without impairing fundamental neural mechanisms of circulatory homeostasis in essential hypertension.
Cite This Study
Mancia et al. (1986) studied this question.