Key result
Acute administration of celiprolol did not alter resting hemodynamics or sympathetic nerve activity, whereas metoprolol significantly decreased forearm blood flow and heart rate.
Why the study?
Does celiprolol differ from metoprolol and placebo in its effects on hemodynamics and sympathetic nerve activity in normal volunteers?
Population
10 normal volunteers
Comparison
Celiprolol (acute administration) vs Metoprolol and placebo
Design
Other
Follow-up
Acute
Authors
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Does not support changing beta-blocker selection from acute volunteer data; leaves open differential effects in patients.
RCT (n=10)
Does celiprolol differ from metoprolol and placebo in its effects on hemodynamics and sympathetic nerve activity in normal volunteers?
Celiprolol lacks the peripheral vasoconstriction seen with metoprolol, likely due to its partial beta-2-receptor agonistic effect rather than central or alpha-blocking effects.
Heusser et al. (2002) conducted an RCT in normal volunteers (n=10). Celiprolol vs. Metoprolol and placebo was evaluated on Sympathetic nerve activity to muscle (MSNA), forearm blood flow (FBF), blood pressure (BP), central venous pressure, and heart rate (HR). Acute administration of celiprolol did not alter resting hemodynamics or sympathetic nerve activity, whereas metoprolol significantly decreased forearm blood flow and heart rate.
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