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What are the mechanisms and effects of different types of β-blockers on arterial properties in hypertensive subjects?
What are the mechanisms and effects of different types of β-blockers on arterial properties in hypertensive subjects?
Different beta-blockers have distinct effects on arterial properties, with bisoprolol improving BRS and vascular stiffness, and celiprolol reducing central blood pressure.
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Supports distinct vascular effects among β-blockers in hypertension; leaves open whether these guide selection or affect outcomes.
The effects of β-blockers on arterial properties are not well investigated. In our recent study, we compared the effects of the two β-blockers celiprolol and bisoprolol on blood pressure, baroreflex sensitivity (BRS), flow-mediated vasodilatation, and vascular stiffness. We found that bisoprolol achieved a greater reduction in the pulse rate and improved BRS and vascular stiffness, whereas celiprolol reduced the central blood pressure level. In this review, the mechanisms of different types of β-blockers and their effects on arteries are discussed, and the appropriate use of β-blockers in hypertensive subjects will be proposed.
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A 2015 study studied this question.
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