November 1, 1996British Journal of PharmacologyOpen Access

Effect of celiprolol therapy on arterial dilatation in experimental hypertension

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Why the study?

Does celiprolol improve arterial dilatation in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats

Comparison

Celiprolol administered for 12 weeks vs Untreated SHR and WKY rats

Design

Preclinical

Follow-up

12 weeks

Authors

JTJari‐Petteri TolvanenTampere University XWXiumin WuHunan Normal University MKMika KähönenPreventive Cardiology

Discussion

Member takes

Implication

Leaves open celiprolol's vascular effects in human hypertension; hypothesis-generating in animal models only.

Structured PICO

Does celiprolol improve arterial dilatation in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats

Intervention

Celiprolol (5 and 50 mg/kg/day for SHR; 50 mg/kg/day for WKY rats) administered for 12 weeks

Comparator

Untreated SHR and WKY rats

Outcome

Responses of mesenteric arterial rings in vitro to acetylcholine, nitroprusside, isoprenaline, noradrenaline, and 5-hydroxytryptaminesurrogate

Celiprolol enhances nitric oxide-mediated arterial relaxation in spontaneously hypertensive rats independently of its blood pressure-lowering effects.

Cite This Study

Tolvanen et al. (1996) studied this question.

synapsesocial.com/papers/6a72c80784cc45bb7be02c4e https://doi.org/10.1111/j.1476-5381.1996.tb16015.x

Topics

Hypertension management

View Full Paper

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Effect of celiprolol therapy on arterial dilatation in experimental hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effect of celiprolol therapy on arterial dilatation in experimental hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider