Why the study?
Does celiprolol improve clinical response, efficacy, and tolerance compared to metoprolol or placebo in patients with stable chronic heart failure?
Population
50 patients with stable chronic heart failure due to idiopathic dilated, ischaemic, or hypertensive…
Comparison
Celiprolol 200 mg daily for three months with a… vs Metoprolol 50 mg twice daily or placebo for…
Design
RCT, randomised, double blind placebo controlled
Follow-up
3 months (double blind) and 1 year (open label)
Authors
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Favor metoprolol over celiprolol in stable chronic HF; extends RCT evidence for differential beta-blocker effects on function.
Does celiprolol improve clinical response, efficacy, and tolerance compared to metoprolol or placebo in patients with stable chronic heart failure?
Celiprolol does not provide additional long-term clinical benefit over metoprolol in patients with chronic heart failure, with metoprolol showing superior improvements in LVEF, NYHA class, and exercise capacity.
Sanderson et al. (1998) studied this question.
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