Why the study?
Does metoprolol or celiprolol improve baroreceptor function and vagal tone in patients with stable chronic heart failure?
Population
50 patients with stable chronic heart failure (and 35 healthy normal subjects as a control group)
Comparison
Metoprolol 50 mg twice daily or celiprolol 200… vs Matching placebo for 12 weeks
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
12 weeks
Authors
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Supports metoprolol over celiprolol for autonomic restoration in stable HF; confirms beta-blocker heterogeneity beyond hemodynamics.
Does metoprolol or celiprolol improve baroreceptor function and vagal tone in patients with stable chronic heart failure?
Metoprolol, but not celiprolol, restores baroreceptor gain and increases vagal tone in chronic heart failure, suggesting differential autonomic benefits among beta-blockers.
Sanderson et al. (1999) studied this question.
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