Key result
Celiprolol reduced atrial natriuretic factor to 74% of basal levels at 24 hours (P=0.019), whereas metoprolol increased it to 112% (P=0.029) in patients with heart failure.
Why the study?
Does celiprolol improve natriuretic peptide levels and hemodynamics compared to metoprolol in patients with heart failure?
RCT (n=20)
Double-blind
Randomized
No
Does celiprolol improve natriuretic peptide levels and hemodynamics compared to metoprolol in patients with heart failure?
Absolute Event Rate: 74% vs 112%
In patients with heart failure, a vasodilating beta-blocker (celiprolol) acutely reduced natriuretic peptide levels and improved cardiac output compared to low-dose metoprolol.
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Celiprolol may confer acute hemodynamic advantage over metoprolol in heart failure; extends evidence for vasodilating beta-blocker differentiation.
Sanderson et al. (1995) conducted an RCT in Heart failure (n=20). Celiprolol vs. Metoprolol 6.25 mg twice daily was evaluated on Plasma concentrations of atrial natriuretic factor (ANF) at 24 hours (% of basal level). Celiprolol reduced atrial natriuretic factor to 74% of basal levels at 24 hours (P=0.019), whereas metoprolol increased it to 112% (P=0.029) in patients with heart failure.
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