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Sublingual long-acting nitrates likely have a 1-2.5 hour duration of action, which is more prolonged than nitroglycerin, though evidence for prolonged action of oral nitrates is lacking.
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The editorial highlights the uncertain duration of action of various nitrate formulations for angina pectoris, calling for further confirmation of nitroglycerin ointment's efficacy.
EDITORlingual long-acting nitrates more prolonged than that achieved by nitroglycerin.It is likely that the duration of ac- tion of the sublingual nitrates is not as long as would be ideal, merely more prolonged than that achieved by nitroglycerin: a 1-21/2 hour duration of action seems most likely.Evidence that oral "long-acting nitrates" have a prolonged duration of action is, we agree, lacking.Although the information that nitroglycerin ointment may be superior is potentially exciting,"O its preliminary nature deserves reconfirmation before its acceptance to the exclusion of the sublingual mode of administration.
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Goldstein et al. (1974) conducted a letter in Angina Pectoris. Sublingual long-acting nitrates vs. Nitroglycerin was evaluated. Sublingual long-acting nitrates likely have a 1-2.5 hour duration of action, which is more prolonged than nitroglycerin, though evidence for prolonged action of oral nitrates is lacking.
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