Key result
Sublingual long-acting nitrates increased mean exercise duration to ischemia at 45 minutes (87.5-89.1 sec) compared to placebo (58.4-62.5 sec; P<0.01), but not at 100 minutes.
Why the study?
Do sublingual long-acting nitrates improve exercise duration to ischemia compared to placebo in hospitalized patients with angina?
RCT (n=10)
Do sublingual long-acting nitrates improve exercise duration to ischemia compared to placebo in hospitalized patients with angina?
p-value: p=<.01
Sublingual long-acting nitrates are effective for at least 45 minutes but lose efficacy by 100 minutes, suggesting they should be used prophylactically before anticipated angina rather than on a fixed schedule.
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Supports prophylactic use before anticipated angina; leaves open optimal timing and sustained efficacy in larger trials.
Klaus et al. (1973) conducted an RCT in Angina (n=10). Sublingual long-acting nitrates vs. Placebo was evaluated on Duration of exercise to the point of ischemia (p=<.01). Sublingual long-acting nitrates increased mean exercise duration to ischemia at 45 minutes (87.5-89.1 sec) compared to placebo (58.4-62.5 sec; P<0.01), but not at 100 minutes.
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