Key result
Carotid artery disease and angina in aortic stenosis patients identified groups with coronary artery disease prevalence ranging from 85% (both present) to 21% (both absent).
Why the study?
Is carotid artery disease associated with coronary artery disease in patients with aortic valve stenosis?
Cross-Sectional (n=317)
Is carotid artery disease associated with coronary artery disease in patients with aortic valve stenosis?
In patients with symptomatic aortic stenosis, the presence of significant carotid artery disease is a strong marker of significant coronary artery disease, which may help risk-stratify these patients.
Answers are grounded in this paper and cite their sources.
May aid CAD risk stratification in aortic stenosis; supports association but leaves open practice change.
BACKGROUND: Patients with aortic stenosis have a high prevalence of coronary artery disease, but there is little information about the association of coronary artery disease and carotid artery disease. METHODS: The study includes 317 consecutive patients with aortic stenosis, who underwent carotid and coronary angiography during the same catheterization before aortic valve replacement. RESULTS: At univariate analysis, the prevalence of coronary artery disease was associated with (1) presence of carotid artery disease (P < .001); (2) angina pectoris as presentation symptom (P < .001); (3) age more than 65 years (P < .05); and (4) hypertension (P < .05). At multivariate analysis, only carotid artery disease, angina, and age emerged as independent predictors of coronary artery disease. The combination of 2 variables (carotid artery disease, angina) allowed the identification of 4 groups, with decreasing prevalence of coronary artery disease: (1) angina+/carotid artery disease+: 85%; (2) angina-/ carotid artery disease+: 50%; (3) angina+/carotid artery disease-: 41%; (4) angina-/carotid artery disease-: 21% (P < .001). CONCLUSION: In patients with symptomatic aortic stenosis, the presence of significant carotid artery disease is a strong marker of significant coronary artery disease.
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Antonini‐Canterin et al. (2008) conducted a cross-sectional in Aortic valve stenosis (n=317). Carotid artery disease vs. Absence of carotid artery disease was evaluated on Prevalence of coronary artery disease (p=<.001). Carotid artery disease and angina in aortic stenosis patients identified groups with coronary artery disease prevalence ranging from 85% (both present) to 21% (both absent).
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