Key result
Endothelin-1 overexpression in mice induced early, reversible electrical remodeling (including reduced Cx40, Cx43, and Nav1.5 expression) that preceded the development of structural heart failure.
Why the study?
Does endothelin-1 overexpression induce electrical remodelling preceding heart failure in a transgenic mouse model?
Does endothelin-1 overexpression induce electrical remodelling preceding heart failure in a transgenic mouse model?
Endothelin-1-mediated electrical remodelling, characterized by reduced connexin and sodium channel expression, precedes and may contribute to the pathogenesis of structural heart failure.
No takes yet. Share an insight, caveat, or question.
Endothelin-1 may be an early therapeutic target in HF; leaves open whether reversible electrical remodeling drives human disease progression.
Mueller et al. (2010) studied Heart failure and cardiomyopathy. Endothelin-1 (ET-1) overexpression via doxycycline withdrawal vs. Non-BT littermate controls was evaluated on Electrophysiological abnormalities, structural and functional remodelling. Endothelin-1 overexpression in mice induced early, reversible electrical remodeling (including reduced Cx40, Cx43, and Nav1.5 expression) that preceded the development of structural heart failure.
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