Key result
Female Spontaneously Diabetic Torii (SDT) rats exhibited significantly impaired glucose tolerance and higher plasma insulin levels at 120 minutes after glucose loading compared to controls (P<0.05).
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Does not inform clinical practice; leaves open translation of female SDT rat glucose intolerance to human diabetes research.
The Spontaneously Diabetic Torii (SDT) rat, a newly established animal model for diabetes mellitus, presents nonobese type 2 diabetes with ocular complications. In the present study, oral glucose tolerance tests and biochemical and histopathological examinations were performed in female SDT rats at 16 and/or 25 weeks of age, before the onset of diabetes. At 25 weeks of age, glucose tolerance was significantly impaired, and plasma immunoreactive insulin levels at 120 min after glucose loading were significantly higher (P < 0.05). Body weight and fasting levels of plasma triglycerides and nonesterified fatty acids were significantly higher than those in control animals. Histopathologically, inflammatory cell infiltration and fibrosis were observed in and around the pancreatic islets. These results strongly suggest that female SDT rats are useful as a model to investigate impairment of glucose tolerance and hyperlipidemia prior to the onset of diabetes.
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Shinohara et al. (2004) studied Diabetes mellitus. Spontaneously Diabetic Torii (SDT) rat phenotype vs. Control animals was evaluated on Plasma immunoreactive insulin levels at 120 min after glucose loading (p=< 0.05). Female Spontaneously Diabetic Torii (SDT) rats exhibited significantly impaired glucose tolerance and higher plasma insulin levels at 120 minutes after glucose loading compared to controls (P<0.05).
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