Key result
High-sucrose diet doubles diabetes incidence at 46 weeks in preclinical model.
Why the study?
The causal role of postprandial hypertriglyceridemia in the development of insulin resistance and type 2 diabetes was unclear.
Does postprandial hypertriglyceridemia predict the development of insulin resistance and type 2 diabetes in a rat model?
Population
96 male Wistar rats in a diet-induced T2DM model
Comparison
High sucrose diet alone vs HSD+Pioglitazone vs HSD+Atorvastatin vs control
Design
Randomized preclinical study
Follow-up
48 weeks
Authors
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PPHTg may drive diet-induced T2DM in rats; leaves open whether postprandial lipid targeting prevents diabetes in humans.
Does postprandial hypertriglyceridemia predict the development of insulin resistance and type 2 diabetes in a rat model?
Absolute Event Rate: 100% vs 45.45%
p-value: p=0.01
In a rat model, postprandial hypertriglyceridemia predicts the development of insulin resistance and type 2 diabetes, an effect that can be mitigated by atorvastatin.
Aslam et al. (2016) studied Insulin resistance and Type 2 Diabetes (n=96). High sucrose diet vs. Standard chow diet was evaluated on Cumulative incidence of diabetes at week 46 (p=0.01). In a rat model, a high sucrose diet inducing postprandial hypertriglyceridemia resulted in a 100% cumulative incidence of diabetes at 46 weeks compared to 45.45% in controls fed a standard diet.
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