What question did this study set out to answer?

To evaluate the efficacy and safety of transition regimens using remifentanil versus morphine sulfate for immediate postoperative pain control following remifentanil and propofol anesthesia.

August 1, 1997AnesthesiologyOpen Access

A Comparison of Remifentanil and Morphine Sulfate for Acute Postoperative Analgesia after Total Intravenous Anesthesia with Remifentanil and Propofol

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To evaluate the efficacy and safety of transition regimens using remifentanil versus morphine sulfate for immediate postoperative pain control following remifentanil and propofol anesthesia.
Multicenter, double-blind, double-dummy randomized trial of 150 patients who received intraoperative remifentanil and propofol anesthesia.
Patients were randomized to receive either titrated remifentanil infusions with placebo boluses or morphine sulfate boluses with placebo infusions until 35 minutes post-extubation.
Successful analgesia at 25 minutes post-extubation occurred in 58% of patients in the remifentanil group compared to 33% in the morphine group (P < 0.05).
At 35 minutes post-extubation, ≥74% of patients across both groups experienced moderate to severe pain after the study infusions stopped.
Transient respiratory depression or apnea occurred in 14% of the remifentanil group versus 6% of the morphine group (P > 0.05).

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Implication

Randomized double-blind trial shows superior immediate analgesia with remifentanil over morphine in surgical patients, indicating rapid drug dissipation requires careful transition planning.

Cite This Study

Yarmush et al. (1997) studied this question.

synapsesocial.com/papers/6a9333be28f2d26a645d0014 https://doi.org/10.1097/00000542-199708000-00009

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Implication

Randomized double-blind trial shows superior immediate analgesia with remifentanil over morphine in surgical patients, indicating rapid drug dissipation requires careful transition planning.

A Comparison of Remifentanil and Morphine Sulfate for Acute Postoperative Analgesia after Total Intravenous Anesthesia with Remifentanil and Propofol

Key Points

Discussion

Implication

Cite This Study

A Comparison of Remifentanil and Morphine Sulfate for Acute Postoperative Analgesia after Total Intravenous Anesthesia with Remifentanil and Propofol

Key Points

Discussion

Implication

Cite This Study

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