Key result
FMDV infection in BHK-38 cells induces distinct membrane rearrangements, including the collapse of cellular organelles to one side of the cell and fewer double-membrane vesicles compared to other picornaviruses.
Population
BHK-38 cells
Comparison
Foot-and-mouth disease virus (FMDV) infection vs Infection with other picornaviruses
Design
Preclinical
Follow-up
1.5-2.0 h post-infection
Authors
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Distinct FMDV membrane rearrangements in BHK cells suggest virus-specific replication; leaves open relevance to pathogenesis or antivirals in livestock.
FMDV induces distinct ultrastructural membrane rearrangements in host cells compared to other picornaviruses.
Monaghan et al. (2004) studied Foot-and-mouth disease virus infection (in vitro). Foot-and-mouth disease virus (FMDV) infection vs. Other picornaviruses (poliovirus, echovirus 11, bovine enterovirus) was evaluated on Membrane rearrangements and viral replication site ultrastructure. FMDV infection in BHK-38 cells induces distinct membrane rearrangements, including the collapse of cellular organelles to one side of the cell and fewer double-membrane vesicles compared to other picornaviruses.
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