Why the study?
Does intravenous diazepam alter the pharmacokinetics of intravenously or epidurally administered bupivacaine in Rhesus monkeys?
Does intravenous diazepam alter the pharmacokinetics of intravenously or epidurally administered bupivacaine in Rhesus monkeys?
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Intravenous diazepam does not alter the pharmacokinetics of intravenously or epidurally administered bupivacaine in a primate model.
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Bruijn et al. (1986) studied this question. Intravenous diazepam vs. Intravenous saline was evaluated on Pharmacokinetic parameters of bupivacaine (total clearance, volume of distribution, mean absorption time).
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