Key result
The F-actin-depolymerizing factor (ADF) in human serum was identified as a 93,000-dalton protein that rapidly shortens actin filaments in a Ca2+-dependent manner without monomeric net release.
Authors
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ADF characterization extends cytoskeletal biology; leaves open its diagnostic or therapeutic relevance in disease.
Thorstensson et al. (1982) studied Leukemia (n=7). F-actin-depolymerizing factor (ADF) was evaluated on ADF concentration and F-actin severing activity. The F-actin-depolymerizing factor (ADF) in human serum was identified as a 93,000-dalton protein that rapidly shortens actin filaments in a Ca2+-dependent manner without monomeric net release.
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