Key result
Exercise training protected rabbit renal circulation against high glucose-induced endothelial dysfunction, maintaining ACh-induced vasodilation compared to sedentary controls (46% vs 19%; P<0.05).
Why the study?
Does exercise training prevent high glucose-induced endothelial dysfunction in the renal circulation of rabbits?
Does exercise training prevent high glucose-induced endothelial dysfunction in the renal circulation of rabbits?
Absolute Event Rate: 46% vs 19%
p-value: p=<0.05
Exercise training protects the rabbit renal circulation against endothelial dysfunction elicited by acute exposure to moderately elevated glucose levels.
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Exercise may preserve renal endothelial function in hyperglycemic rabbit models; leaves open translation to human diabetic kidney disease.
Moraes et al. (2005) studied endothelial dysfunction. Exercise training vs. Sedentary (pen confined) was evaluated on endothelium-dependent vasodilation induced by ACh under high glucose exposure (p=<0.05). Exercise training protected rabbit renal circulation against high glucose-induced endothelial dysfunction, maintaining ACh-induced vasodilation compared to sedentary controls (46% vs 19%; P<0.05).
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