Key result
Left ventricular deafferentation with phenol mildly attenuated reflex sensitivity during volume expansion (from -9.1 to -6.6 percent change in RSNA per mm Hg change in LAP; P<0.05).
Why the study?
Does left ventricular deafferentation alter the control of renal sympathetic nerve activity by the vagal cardiopulmonary reflex in dogs?
Population
Chloralose-anesthetized, mechanically ventilated dogs with sinoaortic denervation (n=38)
Comparison
Application of 88% phenol to either the… vs Application of epicardial saline to the left…
Design
Preclinical
Authors
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Modest LV deafferentation effects confirm cardiopulmonary reflex redundancy in dogs; leaves open dominant receptor contributions for future models.
Does left ventricular deafferentation alter the control of renal sympathetic nerve activity by the vagal cardiopulmonary reflex in dogs?
Absolute Event Rate: -6.6% vs -9.1%
p-value: p=< .05
Interruption of vagal afferent input from the left ventricle has only modest effects on the vagal cardiopulmonary reflex, suggesting considerable redundancy from receptors in the lungs and other cardiac chambers.
Minisi et al. (1994) studied Left ventricular deafferentation (n=38). Left ventricular deafferentation (phenol application) vs. Epicardial saline application (control) was evaluated on Reflex sensitivity (percent change in RSNA per mm Hg change in LAP) during volume expansion (p=< .05). Left ventricular deafferentation with phenol mildly attenuated reflex sensitivity during volume expansion (from -9.1 to -6.6 percent change in RSNA per mm Hg change in LAP; P<0.05).
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