A hormonal disorder prevalent among women during their childbearing years, is polycystic ovarian syndrome (PCOS).Recently the number of women with reproductive age who had PCOS increased to 82.44 per 100,000.The widespread presence of PCOS in India is between 3.7 and 22.5%.In PCOS, levels of hormones such as luteinizing hormone (LH), follicle stimulating hormome (FSH), and progesterone are significantly impacted.It also reduces the susceptibility of the hypothalamus's to progesterone's negative feedback regulation.Theca cells create more testosterone because of these interferences, which leads to anovulation, cysts in the ovary, hirsutism, and acne --all of which are frequent in PCOS.These pathological factors can be utilized in the design of appropriate animal model of PCOS.Currently, tamoxifen, metformin, and clomiphene citrate are the most frequently given drugs for PCOS.Considering these drugs' negative effects and relative efficacy in treating PCOS, it is imperative to discover and develop alternatives.
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Samreen et al. (2024) studied this question.
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