Development and Validation of a UV Spectrophotometric Method for the Determination of Cobicistat in Pharmaceutical Formulations

A novel UV spectrophotometric method was devised and tested to appropriately quantify Cobicistat (COBI) in pharmaceutical formulations.It was discovered that the COBICISTAT wavelength of maximum absorbance was 243.8 nm.For COBI, it was discovered that the system and technique accuracy, given as the % RSD of six duplicate measurements, was 0.4712.It was shown that the COBI mean per cent of recovery ranged from 100.84.For COBI, the limits of detection and quantitation were 0.79 g/ml and 2.154 g/ml, respectively.The relationship between absorbance and COBI concentration was linear between 7.5-37.5 and 15-75 g/ml.The Evotaz tablet dosage form's COBI test resulted in a result of 99.52%.So, it was found that the new way was easy, quick, and good for checking quality control.It is suggested for testing COBICISTAT in pure and tablet forms in any lab for quality control.