Formulation and Evaluation of Chewable Tablets of Cefixime Trihydrate Solid Dispersion with Natural Polymer

Chewable tablets being a versatile dosage form which offer several advantages including oral drug delivery without the need for water, ease of swallowing, the stable solid dosage forms, and patient-centric drug delivery.Guar gum being a natural polymer with several interesting properties like biodegradability, biosafety, biocompatibility and sustainability presents a potential case for use in pharmaceutical formulations and drug release studies.Solid dispersion (SD) is one of the most effective and promising technique used to improve the solubility of poorly water soluble drugs.This technology is mainly applied to improve the solubility of Class II and Class IV drugs.Cefixime is an oral third generation cephalosporin antibiotic most widely used in the treatment of various infections, which has oral bioavailability of 40-50% and it belongs to the BCS Class IV.In the present study, an attempt was made to increase the solubility of Cefixime by preparing its solid dispersions using natural polymer i.e. guar gum.Solvent evaporation method was used for preparing Solid dispersions with different drug-polymer ratio.The prepared solid dispersions were evaluated for preformulation studies, percentage yield, in vitro dissolution studies, dissolution efficiency, FTIR, DSC etc.The result obtained from above studies showed that the solubility and dissolution profile of Cefixime solid dispersions were improved as compared to pure drug.The prepared chewable tablets were evaluated and found to exhibit satisfactory physico-chemical characteristic.