SUMMARY Antihuman lymphocyte serum was produced in horses using spleen cells, blood lymphocytes, blood lymphocyte membranes, and thoracic duct lymphocytes as antigens. Testing in monkeys and chimpanzees indicated that the spleen cells produced sera which had low immunosuppressive activity and some with rather high toxicity. Antisera to blood lymphocytes or blood lymphocyte membranes caused catastrophic thrombocytopoenia. Sera produced using thoracic duct cells gave high rosette-inhibition titres, showed immunosuppressive activity in monkeys, and showed no evidence of acute toxicity in either mice or monkeys
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Woiwod et al. (1970) studied this question.