Key result
Coexpression of Kv4.2 proteins with DPP6-S increased the main unitary conductance from 4.1 pS to 7.7 pS, matching the conductance of native cerebellar granule neuron channels.
Population
Cerebellar granule neurons from wild-type rats and mice, dpp6 knock-out mice, and heterologous expression…
Comparison
Coexpression of Kv4.2 or Kv4.3 channels with… vs Kv4.2 or Kv4.3 channels expressed alone, and…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open validation of DPP6-S modulation in human neuronal disorders.
Absolute Event Rate: 7.7% vs 4.1%
p-value: p=<0.001
DPP6-S is an integral subunit necessary and sufficient to explain the larger unitary conductance of native neuronal Kv4 channels compared to recombinant channels.
Kaulin et al. (2009) studied this question. DPP6-S coexpression vs. Kv4.2 channels expressed alone was evaluated on Main unitary conductance (p=<0.001). Coexpression of Kv4.2 proteins with DPP6-S increased the main unitary conductance from 4.1 pS to 7.7 pS, matching the conductance of native cerebellar granule neuron channels.
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